Mei Liu;Xin Zeng;Chao Ma;Huan Yi;Zeeshan Ali;Xianbo Mou;Song Li;Yan Deng;Nongyue He
Bone Research,2017年5(2):75-94 ISSN：2095-4700
Deng, Yan;He, Nongyue
[Xianbo Mou; Chao Ma; Yan Deng; Nongyue He; Mei Liu; Huan Yi] State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, PR China;[Song Li; Yan Deng; Nongyue He] Hunan Key Laboratory of Green Chemistry and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou, PR China;[Xin Zeng] Nanjing Maternity and Child Health Care Hospital, Nanjing, PR China;[Zeeshan Ali] School of Applied Chemistry and Biotechnology, Shenzhen Polytechnic, Shenzhen, PR China;[Zeeshan Ali] School of Chemistry and Chemical Engineering, Southeast University, Nanjing, PR China
[Deng, Yan; He, Nongyue] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing, Jiangsu, Peoples R China.;[Deng, Yan; He, Nongyue] Hunan Univ Technol, Hunan Key Lab Green Chem & Applicat Biol Nanotech, Zhuzhou, Peoples R China.
Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.