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Current progress in gene delivery technology based on chemical methods and nano-carriers.

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成果类型:
期刊论文
作者:
Jin, Lian;Zeng, Xin;Liu, Ming;Deng, Yan;He, Nongyue
通讯作者:
He, NY
作者机构:
[He, Nongyue; Deng, Yan; Liu, Ming; Jin, Lian] 1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
[He, Nongyue; Deng, Yan] 3. Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province, Hunan Key Laboratory of Green Packaging and Biomedical Nanotechnology, Hunan University of Technology, Zhuzhou 412007, China
[Zeng, Xin] 2. Nanjing Maternal and Child Health Medical Institute, Nanjing Maternal and Child Health Hospital Affiliated of Nanjing Medical University, Nanjing 210029, China
通讯机构:
[He, NY] Southeast Univ, Sipailou 2, Nanjing 210096, Jiangsu, Peoples R China.
语种:
英文
关键词:
Non-viral;Gene delivery;Vectors;Chemical Methods
期刊:
THERANOSTICS
ISSN:
1838-7640
年:
2014
卷:
4
期:
3
页码:
240-255
文献类别:
WOS:Review
所属学科:
ESI学科类别:临床医学;WOS学科类别:Medicine, Research & Experimental
入藏号:
WOS:000334663900002;PMID:24505233
基金类别:
National Key Program for Developing Basic Research of China [2010CB933903, 2014CB744501]; NSFC [61271056, 31201003]; Hunan Science and Technology Projects [2012SK3105]; Scientific Research Fund of Hunan Provincial Education Department [11A030]; China Postdoctoral Science Foundation [20100471362, 2012M520980, 2012M511660]; Jiangsu Postdoctoral Science Foundation [1301093C]; State Key Laboratory of Bio-electronics, Southeast University, China [2013G10]; Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province
机构署名:
本校为其他机构
院系归属:
包装与材料工程学院
摘要:
Gene transfer methods are promising in the field of gene therapy. Current methods for gene transfer include three major groups: viral, physical and chemical methods. This review mainly summarizes development of several types of chemical methods for gene transfer in vitro and in vivo by means of nano-carriers like; calcium phosphates, lipids, and cationic polymers including chitosan, polyethylenimine, polyamidoamine dendrimers, and poly(lactide-co-glycolide). This review also briefly introduces applications of these chemical methods for gene delivery.
参考文献:
Zhang L, 2008, CLIN PHARMACOL THER, V83, P761, DOI 10.1038/sj.clpt.6100400
Santos JL, 2010, J CONTROL RELEASE, V144, P55, DOI 10.1016/j.jconrel.2010.01.034
Thomas M, 2005, PHARM RES, V22, P373, DOI 10.1007/s11095-004-1874-y
Zhou XF, 2008, BIOMATERIALS, V29, P111, DOI 10.1016/j.biomaterials.2007.09.007
Nakhlband A, 2010, J BIOMED NANOTECHNOL, V6, P360, DOI 10.1166/jbn.2010.1131

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