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Coaxially electrospun core/shell structured poly(L-lactide) acid/chitosan nanofibers for potential drug carrier in tissue engineering.

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成果类型:
期刊论文
作者:
Ji, Xuyuan;Yang, Wenjing;Wang, Ting;Mao, Chun;Guo, Lingling;Xiao, Jiangqiang;He, Nongyue*
通讯作者:
He, Nongyue
作者机构:
[ Mao, Chun ] School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, China
[ Yang, Wenjing ] School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, China
[ He, Nongyue ] Hunan Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou, China
[ Wang, Ting ; He, Nongyue ; Guo, Lingling ; Ji, Xuyuan ] State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Nanjing, China
[ Xiao, Jiangqiang ] Department of Hepatobiliary Surgery, Nanjing University Medical School, Nanjing, China
通讯机构:
[He, NY] Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China.
语种:
英文
关键词:
Blood compatibility - Brunauer-emmett-teller surface areas - Coaxial electrospinning - Core/shell structure - High molecular weight - Infrared spectrometry - Poly (l-lactide) - Preparation conditions
期刊:
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
ISSN:
1550-7033
年:
2013
卷:
9
期:
10
页码:
1672-1678
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:生物学与生物化学;WOS学科类别:Materials Science, Biomaterials;Nanoscience & Nanotechnology
入藏号:
WOS:000323236300002;EI:20150800539965;PMID:24015496
基金类别:
973 Project [2010CB33903]; NSFC [61271056, 21205036, 11204033]; Hunan Provincial Natural Science Foundation of China [12JJ6060, 12JJ4049]; Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University [2011E27]; Chinese Postdoctoral Science Foundation [2012M520980, 2012M511660]
机构署名:
本校为其他机构
院系归属:
包装与材料工程学院
摘要:
Biodegradable core/shell structured poly(L-lactide) acid (PLLA)/chitosan (CS) nanofibers were fabricated by coaxial electrospinning. PLLA and CS were dissolved in dichloromethane and aqueous acetic acid solvents for spinning into core and shell layers, respectively. CS of high molecular weight was difficult to spin into nanofibers by electrospinning due to its high viscosity, but it was easier to achieve by coaxial electrospinning with PLLA. The preparation conditions were optimized by changing the ratios of PLLA/CS under different jet voltages. After being investigated by scanning electron microscope (SEM), a smooth structure was prepared using 2% CS as the shell solution with applied voltage 15 kV. Transmission electron microscopy (TEM) study and infrared spectrometry (IR) characterization of PLLA/CS nanofibers indicated that the core/shell structure was successfully fabricated. Brunauer-Emmett-Teller (BET) surface area and pore size distribution exhibited higher capacity of PLLA/CS than PLLA used as drug carrier in tissue engineering. The cytocompatibility of nanofibers were evaluated by co-cultured with human bone marrow-derived UE7T-13 cells, the 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) test exhibited good proliferation of PLLA/CS for cells. Results of blood compatibility tests showed decreased hemolytic ratio and platelets adhesion of PLLA/CS compared with PLLA. The results indicated that PLLA/CS nanofibers could be potential drug carrier for tissue engineering. Copyright ©2013 American Scientific Publishers All rights reserved.
参考文献:
Ahmed M, 2012, J NANOSCI NANOTECHNO, V12, P4775, DOI 10.1166/jnn.2012.4884
Andrade FK, 2011, J BIOMED MATER RES A, V98A, P554, DOI 10.1002/jbm.a.33148
Basuli U, 2012, J NANOSCI NANOTECHNO, V12, P7641, DOI 10.1166/jnn.2012.6627
Brito LM, 2012, J NANOSCI NANOTECHNO, V12, P4508, DOI 10.1166/jnn.2012.6176
Broekema FI, 2011, J MATER SCI-MATER M, V22, P1081, DOI 10.1007/s10856-011-4276-9

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