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Synthesis of Dynamic-Covalent Shell Crosslinkable Core-Shell-Corona Nanoparticles with Boronic Ester Linkages: A Potential Carrier for Drug Delivery

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WOS被引频次:11
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成果类型:
期刊论文
作者:
Xu, Jianxiong;Xie, Shaowen;Tan, Haihu;Li, Na;Zhang, Changfan;Xu, Lijian
通讯作者:
Xu, LJ
作者机构:
[Xu, Lijian; Tan, Haihu; Xu, Jianxiong; Xie, Shaowen] Hunan Univ Technol, Coll Life Sci & Chem, Hunan Key Lab Green Packaging & Applicat Biol Nan, Zhuzhou 412007, Peoples R China.
[Li, Na] Hunan Univ Technol, Coll Met & Mat Engn, Zhuzhou 412007, Peoples R China.
[Zhang, Changfan] Hunan Univ Technol, Coll Elect & Informat Engn, Zhuzhou 412007, Peoples R China.
通讯机构:
[Xu, Lijian] Hunan Univ Technol, Coll Life Sci & Chem, Hunan Key Lab Green Packaging & Applicat Biol Nan, Zhuzhou 412007, Peoples R China.
语种:
英文
关键词:
Dynamic-Covalent;Polymerization Induce Self-Assembly;Boronic Ester Linkage;Core-Shell-Corona Nanoparticle;Drug Delivery
期刊:
NANOSCIENCE AND NANOTECHNOLOGY LETTERS
ISSN:
1941-4900
年:
2017
卷:
9
期:
9
页码:
1346-1355
文献类别:
WOS:Article
所属学科:
ESI学科类别:材料科学;WOS学科类别:Materials Science, Multidisciplinary;Nanoscience & Nanotechnology;Physics, Applied
入藏号:
基金类别:
National Science Foundation of China [21404036, 21501056, 61473117, 51574121]; Scientific Research Fund of Hunan Provincial Education Department [15A048]
机构署名:
本校为第一且通讯机构
院系归属:
包装与材料工程学院
电气与信息工程学院
冶金工程学院
摘要:
Dynamic-covalent shell crosslinkable core-shell-corona nanoparticles (DCSCNs) with boronic ester linkages were synthesized employing two macro-RAFT agents of poly(N, N-dimethylacrylamide)-b-poly(3-acrylamidophenylboronic acid) trithiocarbonate (PDMA-b-PAPBA-TTC) and poly(N, Ndimethylacrylamide)-b-poly(5-Ethyl-2,2-dimethyl-1,3-dioxane-5-yl) methyl acrylate trithiocarbonate (PDMA-b-EDMA-TTC) in dispersion reversible addition-fragmentation chain transfer (RAFT) polymerization of styrene (St) and subsequent pH stimulation. Polymerization led to the formation of PDMA-b-PEDMA-PS/PDMA-b-PAPBA-PS multicompartment triblock copolymer nanoparticles, in which the PDMA block formed the corona, the mixed PAPBA and PEDMA blocks formed the shell, and the solvophobic PS block formed the core. Since the 1,3-dioxane ring in PEDMA block can be hydrolyzed into diol groups under acidic condition, DCSCNs were prepared due to the dynamic-covalent nature of the boronic ester cross-links between the phenylboronic acid and diol groups. It was found that the DCSCNs were pH-responsive in water. Consequently, under the pH value of 3.8 to 7.0, shell crosslinked core-shell-corona nanoparticles were formed, while when the pH value was above 7.0 or below 3.8, decrosslinking of the shell happened. This kind of DCSCNs had potential application as in vivo delivery of anticancer drugs and gene vectors.
参考文献:
Akimoto J, 2014, J CONTROL RELEASE, V193, P2, DOI 10.1016/j.jconrel.2014.06.062
Amamoto Y, 2010, MACROMOLECULES, V43, P1785, DOI 10.1021/ma902413f
Bae SB, 2015, J NANOSCI NANOTECHNO, V15, P7962, DOI 10.1166/jnn.2015.11232
Bapat AP, 2011, J AM CHEM SOC, V133, P19832, DOI 10.1021/ja207005z
Cheng F, 2011, POLYM CHEM-UK, V2, P2122, DOI 10.1039/c1py00123j

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