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Fabrication of an electrochemical biosensor array for simultaneous detection of L-glutamate and acetylcholine.

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成果类型:
期刊论文
作者:
Deng, Yan;Wang, Wei;Ma, Chao;Li, Zhiyang
通讯作者:
Deng, Y.(dy_dengyan@yahoo.com.cn)
作者机构:
[Deng, Yan ; Wang, Wei ] Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou 412007, China
[Deng, Yan ; Ma, Chao ; Li, Zhiyang ] State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
通讯机构:
[Deng, Yan] Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou 412007, China.
语种:
英文
关键词:
Acetylcholinesterase - Carbon paste electrode - Electrochemical biosensor - Glutamate - Neurotransmitter
期刊:
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
ISSN:
1550-7033
年:
2013
卷:
9
期:
8
页码:
1378-1382
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:生物学与生物化学;WOS学科类别:Materials Science, Biomaterials;Nanoscience & Nanotechnology
入藏号:
WOS:000322605500009;EI:20133216577802;PMID:23926804
基金类别:
National Key Program for Developing Basic Research of China [2010CB933903]; NSFC [60971045, 21205013, 21205036, 61271056, 61201033]; Hunan Science and Technology Projects [2012SK3105, 2010sk2003]; Natural Science Foundation of Hunan Province [12JJ6060, 12JJ9038]; Scientific Research Fund of Hunan Provincial Education Department [11A030]; China Postdoctoral Science Foundation [2012M520980]
机构署名:
本校为通讯机构
院系归属:
包装与材料工程学院
摘要:
Using two nano-porous pseudo carbon paste electrodes (Nano-PPCPEs) as the working electrodes, a saturated calomel electrode as the reference electrode, and a Pt electrode as the counter electrode to form a four-electrode system, a novel type of glutamate-acetylcholine electrochemical biosensor array was successfully fabricated. It was shown that the biosensor array displayed a high selectivity and sensitivity and the selective and simultaneous determination of glutamate and acetylcholine (ATCh) is feasible. For L-glutamate, a linear range from 5&times;10<sup>-7</sup> M to 1&times;10<sup>-5</sup> M with the detection limit of 2.5&times;10<sup>-7</sup> M was demonstrated, while for ATChI the linear range is from 5&times;10<sup>-6</sup> M to 2&times;10<sup>-4</sup> M with the detection limit of 1.5&times;10<sup>-7</sup> M. This research means a possibility to simultaneously detect more neurotransmitters with a nano-PPCPEs electrochemical biosensor array. Copyright &copy;2013 American Scientific Publishers All rights reserved.
参考文献:
Ali Z, 2012, J NANOSCI NANOTECHNO, V12, P8241, DOI 10.1166/jnn.2012.6692
Arduini F, 2012, ELECTROANAL, V24, P581, DOI 10.1002/elan.201100540
Bazaka K, 2012, MATER EXPRESS, V2, P285, DOI 10.1166/mex.2012.1086
Chan SHS, 2012, PEDIATR NEUROL, V47, P137, DOI 10.1016/j.pediatrneurol.2012.04.022
Deng Y, 2013, J BIOMED NANOTECHNOL, V9, P318, DOI 10.1166/jbn.2013.1487

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